Abstract:
Introduction: Coccidioidomycosis is a systemic fungal infection caused by dimorphic fungi. Two species are known: C. immitis and C. posadasii.
It is acquired by inhalation of arthroconidia, the infection is usually benign, but in patients whose immunity is compromised, it is severe and may be fatal. In addition to lung disease, it can spread and cause infections in skin, subcutaneous tissue, brain, bones, joints, and others organs.
Objective: to present a case of systemic coccidioidomycosis, which was not diagnosed clinically and had problems of diagnosis in postmortem study, because of the presence of multiple micro calcifications.
Material and Methods: postmortem study of a 55-year-old male patient with chronic pulmonary condition. In-hospital studies, no specific diagnosis was obtained. Histological sections stained with hematoxylin-eosin, PAS and Grocott were performed.
Results: Grossly, nodular lesions, some indurated, up to 1.5 cm in diameter, in lungs, liver, spleen, mesentery, omentum and kidneys were found. The microscopic examination showed chronic inflammation with formation of granulomas and giant cells, abundant calcified organisms, endospores and arthroconidios. Microorganisms were identified by H & E staining, PAS and Grocott.
Conclusion: The case corresponds to a disseminated coccidioidomycosis with numerous calcified microorganisms, which hampered the diagnostic interpretation.