Objective: to determine the prevalence of mortality associated to COVID-19 in patients with chronic kidney disease. Material and methods: descriptive and  prospective study, carried out on 151 adult patients with chronic kidney disease who present COVID-19 infection and assisted to the permanent attention center of respiratory diseases in Hospital General San Juan de Dios, demographic characteristics, comorbidities, renal replacement therapy, kidney function tests and potassium, time of chronic kidney disease diagnosis and ventilatory support were determined, a data collection instrument was elaborated with all the variables of the study. Results: 57 (37.7%) of the total population of patients died, 66.7% were male, 35.1% had ages between 46-55 years, 78.9% had diabetes mellitus, 89.5% were undergoing hemodialysis therapy, 19.3% of patients were under invasive ventilatory support, 26 of these patients (45.6%) had more tan 11 days without dialytic therapy, according to laboratory findings 47.4% had creatinine levels between 9.1 and 12 mg/dL, 38.6% had blood urea nitrogen levels amid 90.1 and 110 mg/dL and potassium levels between 5.51 and 6.5 mmol/L. Conclusions: mortality associated to COVID-19 in chronic kidney disease patients was of 37.7%, this group of patients present an extended time amid each dialytic therapy and a higher mortality risk.