Knee osteoarthritis is a chronic disease with a high world prevalence. When human populations become older, the number of people affected rise with a great impact in the quality of life. The treatment of this disease has been difficult and collateral effects may be dangerous. The chronicity of the disease requires prolonged treatments with worst collateral effects and high costs. The intraarticular application of platelet rich plasma has been utilized for a long period with few collateral effects reported, but, the costs are high when certain procedures are used for the collection of the plasma. In this report we describe the demographic characteristics of 29 people treated in the Physical Medicine and Rehabilitation Department at the San Juan de Dios Hospital. All patients have reported beneficial effects and practically none important collateral effect. The samples were obtained in the Clinic Laboratory at the Hospital, where, with the actual equipment and personal is obtained with a very low cost. This resources are available in every hospital in our country, we propose its utilization with an important reduction in costs and a great impact in the quality of life of the affected persons.