Multidisciplinary approach in the management of brain metastases from lung adenocarcinoma.
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lung cancer
radiotherapy
target therapy
inmunotherapy
medical oncology
Abstract
Brain metastases in lung adenocarcinoma are common and often present as complications in patients with advanced cancer. It worsen prognosis and reduce survival. Clinically, they vary from asymptomatic to intracranial hypertension syndrome. Multidisciplinary approach is crucial in determining the best treatment. Diagnostic methods such as computed tomography and magnetic resonance imaging are useful in detecting brain metastases and determining the amount and location of the lesions. Surgical treatment of brain metastases combined with radiotherapy is considered the most effective approach to reduce lesion size and improve neurological symptoms. Radiotherapy is a treatment option for patients who are not candidates for surgery or for those with multiple brain lesions. Targeted therapy, such as inhibition of epidermal growth factor receptor (EGFR) kinase, has significantly improved survival in patients with metastatic lung adenocarcinoma. Immune checkpoint inhibitor therapy has also been shown to be effective in patients with advanced lung adenocarcinoma and brain metastases. In conclusion, brain metastases in lung adenocarcinoma are a common complication in patients with advanced cancer and significantly affect quality of life and prognosis. Multidisciplinary approach is crucial in evaluating the disease stage and determining the best treatment, which may include surgery, radiotherapy, targeted therapy, and immunotherapy.
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