Characterization of changes by regression in pilocytic astrocytoma
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brain
Neoplasm Regression
Abstract
Background. Pilocytic astrocytoma is the most common Central Nervous System (CNS) tumor in the pediatric population, belonging to WHO grade 1. It has an excellent prognosis with complete resection. Growth arrest and tumor regression have also been documented, affecting the patient's prognosis and survival. Objetive. To determine the prevalence and the characteristics of pilocytic astrocytomas with regressive changes at the Hospital General de Enfermedades del Instituto Guatemalteco de Seguridad Social, as well as the survival of patients. Material and methods. The present study was conducted at the Guatemalan Institute of Social Security, from April 2013 to June 2022. From the database composed of 221 cases of neuroepithelial tumors, pilocytic astrocytomas were identified, and of these, those that showed regression changes. Results. Five cases of pilocytic astrocytoma were identified and characterized. Conclusion. The regression change represented a prevalence of 35.7% of all pilocytic astrocytomas studied.
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References
Louis D, Ohgaki H, Wiester O, et al. WHO classification of Tumors of the Central Nervous System. 5th ed. Lyon, France: Internacional Agency for Research on Cancer, Editorial Board.; 2021. 83–89 p.
Loh JK, Lieu AS, Chai CY, Hwang SL, Kwan AL, Wang CJ, et al. Arrested growth and spontaneous tumor regression of partially resected low-grade cerebellar astrocytomas in children. Child’s Nervous System. 2013 Nov 1;29(11):2051–5.
Sattar S, Akhunzada N, Javed G, Uddin Z, Khan Y. Pilocytic astrocytoma: A rare presentation as intraventricular tumor. Surgical Neurology International. 2017;8(1):116.